IQGAP1在哈萨克族食管癌组织中的表达及意义

doi:10.3969/j.issn.1004-616x.2012.02.011

›› 2012, Vol. 24 ›› Issue (2): 129-131.doi: 10.3969/j.issn.1004-616x.2012.02.011

The expression and clinical significance of IQGAP1 in esophageal cancer of Kazaks

Received:2011-11-17 Revised:2011-12-25 Online:2012-03-30 Published:2012-03-30
Contact: CHEN Hong-ming

Abstract

Abstract: OBJECTIVE: To investigate the expression of IQGAP1 in esophageal cancer tissues and its relationship between their expressions and the clinical pathological features in Kazaks. METHODS：The mRNA expression level of IQGAP1 in 48 Kazak's esophageal cancer specimens were measured by RT-PCR. The relationship between clinical pathologic features and expressions of IQGAP1mRNA level was analyzed. RESULTS：The expression of IQGAP1 mRNA in cancer tissues was (50%) significantly higher than that of normal tissues (P<0.05). However，the expression level of IQGAP1 mRNA was not significantly related to the degree of differentiation，depth of invasion and lymph node metastasis. CONCLUSION：IQGAP1 gene expression may be related to the development of esophageal cancer with Kazak.

Key words: Kazak, esophageal neoplasms, IQ domain GTPase-activating protein 1

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The expression and clinical significance of IQGAP1 in esophageal cancer of Kazaks

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